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| Nomenclature |
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Symbol:
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G6pctm1Jyc
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Name:
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glucose-6-phosphatase, catalytic;
targeted mutation 1, Janice Yang Chou
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MGI ID: |
MGI:2387343 |
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Synonyms: |
G6Pase-, Glc-6-Pase-alpha- |
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Gene:
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G6pc
Location:
Chr11:101367561-101377903 bp, + strand
Genetic Position: Chr11,
64.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:33212
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a neomycin selection cassette via homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by a protection assay and Western blot analysis of liver and kidney tissues. Functional ablation was confirmed by the absence of glucose-6-phosphate hydrolysis in liver and kidney microsomes obtained from homozygous mutant mice. (J:33212)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any G6pc Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:33212
Lei KJ et al.,
"Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse."
Nat Genet 1996 Jun;13(2):203-9
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All: |
10 reference(s)
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Analysis Tools
