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| Nomenclature |
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Symbol:
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Brca2tm1Mbn
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Name:
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breast cancer 2;
targeted mutation 1, L Michelle Bennett
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MGI ID: |
MGI:2387337 |
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Synonyms: |
B2-, Brca2 delta10/11 |
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Gene:
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Brca2
Location:
Chr5:150522630-150569746 bp, + strand
Genetic Position: Chr5,
89.52 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:74077
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Parent Cell Line:
| BK4 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Nucleotides 1745 to 2033, encompassing portions of exons 10 and 11 and the intervening intron, were replaced with a neomycin selection cassette. RT-PCR and sequence analyses identified an aberrant transcript containing the first 569 codons of the endogenous gene fused to 75 neo codons. This transcript was undetected by Northern blot analysis, indicating that it was unstable. (J:74077)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Brca2 Mutation:
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32 strains or lines available |
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| References |
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Original: |
J:74077
Bennett LM et al.,
"BRCA2-null embryonic survival is prolonged on the BALB/c genetic background."
Mol Carcinog 2000 Jul;28(3):174-83
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All: |
2 reference(s)
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Analysis Tools
