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| Nomenclature |
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Symbol:
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Erbb2tm1Klee
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Name:
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v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian);
targeted mutation 1, Kuo-Fen Lee
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MGI ID: |
MGI:2387154 |
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Synonyms: |
erbB2 floxed |
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Gene:
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Erbb2
Location:
Chr11:98412470-98437716 bp, + strand
Genetic Position: Chr11,
61.75 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:76196
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A 3.0 kb region containing 1.5 kb of the endogenous promoter and exon 1 was flanked by loxP sites. Exon 1 encodes amino acids 1 through 27. (J:76196)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Erbb2 Mutation:
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8 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Hirschsprung Disease in mice homozygous for this allele and hemizygous for Tg(Nes-cre)1Atp (J:81239)
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| References |
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Original: |
J:76196
Crone SA et al.,
"ErbB2 is essential in the prevention of dilated cardiomyopathy."
Nat Med 2002 May;8(5):459-65
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All: |
5 reference(s)
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Analysis Tools
