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| Nomenclature |
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Symbol:
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CrygdAey4
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Name:
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crystallin, gamma D;
dominant cataract 4
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MGI ID: |
MGI:2387106 |
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Synonyms: |
Aey4 |
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Gene:
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Crygd
Location:
Chr1:65061872-65063452 bp, - strand
Genetic Position: Chr1,
32.8 cM
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Morphological description and histological comparison of lenses and eyes of CrygdAey4/CrygdAey4 mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3HeB/FeJ
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: A T-to-A transversion at nucleotide position 227 of the cDNA is predicted to result in a substitution of valine at position 76 with an aspartic acid in the encoded protein. This amino acid residue belongs to a structurally conserved region within the second Greek Key motif. (J:78154)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Crygd Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:78154
Graw J et al.,
"V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice."
Mamm Genome 2002 Aug;13(8):452-5
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All: |
2 reference(s)
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Analysis Tools
