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| Nomenclature |
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Symbol:
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Dnase1tm1Tmo
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Name:
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deoxyribonuclease I;
targeted mutation 1, Tarik Moroy
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MGI ID: |
MGI:2387029 |
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Synonyms: |
Dnase1- |
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Gene:
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Dnase1
Location:
Chr16:4036942-4040024 bp, + strand
Genetic Position: Chr16,
2.37 cM, cytoband A1-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62549
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: All 9 exons were removed and replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of RNA from parotids, kidney, and small intestine from homozygous mutant animals, using a rat cDNA probe, did not detect gene expression. Zymograms of cell extracts from parotids, small intestines, kidneys, urine, and serum of homozygous animals demonstrated the absence of enzyme activity. (J:62549)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dnase1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:62549
Napirei M et al.,
"Features of systemic lupus erythematosus in Dnase1-deficient mice [see comments]"
Nat Genet 2000 Jun;25(2):177-81
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All: |
6 reference(s)
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Analysis Tools
