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| Nomenclature |
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Symbol:
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Il6sttm1Thir
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Name:
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interleukin 6 signal transducer;
targeted mutation 1, Toshio Hirano
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MGI ID: |
MGI:2386991 |
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Synonyms: |
F759, gp130F759 |
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Gene:
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Il6st
Location:
Chr13:112475008-112506860 bp, + strand
Genetic Position: Chr13,
63.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:59922
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A human Il6st cDNA fragment carrying a tyrosine to phenylalanine substitution at position 759 (Y759F), was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. The expression level of the mutant protein in B- and T-cells is similar to that of wild-type as determined by flow cytometry. (J:59922)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:59922
Ohtani T et al.,
"Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses."
Immunity 2000 Jan;12(1):95-105
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All: |
16 reference(s)
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Analysis Tools
