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| Nomenclature |
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Symbol:
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Jag1Mhdahtu
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Name:
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jagged 1;
Martin Hrabe de Angelis headturner
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MGI ID: |
MGI:2386949 |
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Synonyms: |
ABE2, Gsfabe2, headturner, Htu, Jag1Htu |
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Gene:
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Jag1
Location:
Chr2:137081456-137116644 bp, - strand
Genetic Position: Chr2,
67.73 cM
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Inner ear of Jag1Mhdahtu/Jag1+ mice at E16.5 shows missing or smaller ampullae
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3HeB/FeJ
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: Genomic sequence analysis of the coding region revealed a G-to-A missense mutation at position 1134, resulting in a nonconservative amino acid substitution of a glycine by an aspartic acid residue. (J:72108)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:72108
Kiernan AE et al.,
"The Notch ligand Jagged1 is required for inner ear sensory development."
Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3873-8
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All: |
6 reference(s)
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Analysis Tools
