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| Nomenclature |
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Symbol:
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Vegfatm4Pec
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Name:
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vascular endothelial growth factor A;
targeted mutation 4, Peter Carmeliet
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MGI ID: |
MGI:2386595 |
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Synonyms: |
VEGF188 |
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Gene:
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Vegfa
Location:
Chr17:46016993-46032369 bp, - strand
Genetic Position: Chr17,
22.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75507
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Genomic sequence containing exons 4 through 8 was replaced with corresponding cDNA. The resultant allele lacks splice sites and thereby produces a single isoform with high receptor binding properties. The exclusive presence of this isoform was verified by quatitative RT-PCR. (J:75507)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:75507
Stalmans I et al.,
"Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms."
J Clin Invest 2002 Feb;109(3):327-36
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All: |
5 reference(s)
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Analysis Tools
