|
|
| Nomenclature |
|
Symbol:
|
Tg(Wnt1-cre)11Rth
|
|
Name:
|
transgene insertion 11, David H Rowitch
|
|
MGI ID: |
MGI:2386570 |
|
Synonyms: |
Wnt1cre, Wnt1-Cre, Wnt1::Cre |
|
Transgene:
|
Tg(Wnt1-cre)11Rth
Location:
unknown
Genetic Position: Chr11,
Syntenic
|
|
Show the 3 image(s) involving this allele.
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6J x CBA/J)F1/J
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (Cre/Flp) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. (J:69326)
|
|
|
Recombinase activity
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
|
| References |
|
Original: |
J:69326
Danielian PS et al.,
"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase."
Curr Biol 1998 Dec 3;8(24):1323-6
|
|
All: |
315 reference(s)
|
|
Analysis Tools
