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| Nomenclature |
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Symbol:
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Tg(Nes-cre)1Wme
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Name:
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transgene insertion 1, Werner Muller
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MGI ID: |
MGI:2386545 |
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Synonyms: |
bal1, Bal1 cre, balancer1, Nestin-Cre, SLNE4c, Tg(balancer1)2Cgn, TgN(balancer1)1Cgn, TgN(balancer1)2Cgn |
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Transgene:
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Tg(Nes-cre)1Wme
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct contained a nestin promoter followed by cre recombinase sequence adjoined to a nuclear localization signal. Intron 2 of the nestin gene was included upstream of a polyadenylation signal. While the endogenous nestin promoter is CNS-specific, Southern blot analysis showed the ubiquitous expression of cre in transgenic mice. Variable mosaicism/partial deletion of loxP-flanked alleles occurs before embryonic day 10.5, and it is detectable in all adult organs examined including germ line cells. (J:67926)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice carrying this "balancer 1" transgene show less variability and instability in their generation of mosaics than do transgenic mice carrying the "balancer 2" transgene.
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| References |
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Original: |
J:67926
Betz UA et al.,
"Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination."
Curr Biol 1996 Oct 1;6(10):1307-16
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All: |
44 reference(s)
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Analysis Tools
