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| Nomenclature |
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Symbol:
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Wrntm1Lgu
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Name:
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Werner syndrome homolog (human);
targeted mutation 1, Leonard Guarente
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MGI ID: |
MGI:2386438 |
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Synonyms: |
WRN- |
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Gene:
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Wrn
Location:
Chr8:33234384-33385527 bp, - strand
Genetic Position: Chr8,
20.3 cM, cytoband A4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:61567
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The 3'-most exon encoding part of the catalytic helicase domain was replaced with a beta-geo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of ear fibroblasts derived from homozygous mutant animals. No protein product was detected using antibodies directed against the N- and C-terminal regions of Wrn. (J:61567)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:61567
Lombard DB et al.,
"Mutations in the WRN gene in mice accelerate mortality in a p53-null background."
Mol Cell Biol 2000 May;20(9):3286-91
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All: |
5 reference(s)
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Analysis Tools
