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| Nomenclature |
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Symbol:
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Ikbkgtm1Mpa
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Name:
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inhibitor of kappaB kinase gamma;
targeted mutation 1, Manolis Pasparakis
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MGI ID: |
MGI:2386324 |
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Synonyms: |
NemoD, Nemohko |
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Gene:
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Ikbkg
Location:
ChrX:74393290-74453854 bp, + strand
Genetic Position: ChrX,
38.0 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63055
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Flanking loxP sites were introduced to exon 2 and an FRT-flanked neomycin resistance cassette was inserted into the downstream intron via homologous recombination. Deletion of exon 2 and the neo cassette was carried out by transient expression of cre and flp recombinases in correctly targeted ES cells. Western blot analysis of mouse embyonic fibroblasts cultured from E12.5 homozygous mutant embryos confirmed the null allele. It was also shown that the targeted mutation did not interfere with neighboring gene G6pdx. (J:63055)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ikbkg Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:63055
Schmidt-Supprian M et al.,
"NEMO/IKK gamma-deficient mice model incontinentia pigmenti."
Mol Cell 2000 Jun;5(6):981-92
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All: |
4 reference(s)
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Analysis Tools
