|
|
| Nomenclature |
|
Symbol:
|
Tyrobptm1.1Viv
|
|
Name:
|
TYRO protein tyrosine kinase binding protein;
targeted mutation 1.1, Eric Vivier
|
|
MGI ID: |
MGI:2386271 |
|
Synonyms: |
DAP12-, DAP12KI, Kdelta75, KDeltaY75 |
|
Gene:
|
Tyrobp
Location:
Chr7:30413788-30417577 bp, + strand
Genetic Position: Chr7,
17.45 cM, cytoband B
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:64764
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The floxed neo cassette was excised from Tyrobptm1Viv via ubiquitous in vivo expression of cre recombinase. RT-PCR analysis showed that the sequence inserted to replace a region encoding a portion of the immunoreceptor tyrosine-based activation motif (ITAM) was left intact along with a single upstream loxP site. (J:64764)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:64764
Tomasello E et al.,
"Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice."
Immunity 2000 Sep;13(3):355-64
|
|
All: |
18 reference(s)
|
|
Analysis Tools
