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| Nomenclature |
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Symbol:
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Pdcd1tm1Hon
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Name:
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programmed cell death 1;
targeted mutation 1, Tasuku Honjo
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MGI ID: |
MGI:2386184 |
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Synonyms: |
PD-1- |
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Gene:
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Pdcd1
Location:
Chr1:94038307-94052553 bp, - strand
Genetic Position: Chr1,
47.47 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50688
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A region encoding both transmembrane and cytoplasmic domains was deleted by the replacement of sequence extending from within exon 3 through a portion of exon 4 with a neomycin selection cassette. Flow cytometric analysis of cultured cells derived from homozygous mutant mice showed a lack of protein expression on the cell surface. (J:50688)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:50688
Nishimura H et al.,
"Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses."
Int Immunol 1998 Oct;10(10):1563-72
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All: |
70 reference(s)
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Analysis Tools
