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| Nomenclature |
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Symbol:
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Zfpm2tm1Sho
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Name:
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zinc finger protein, multitype 2;
targeted mutation 1, Stuart Orkin
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MGI ID: |
MGI:2386183 |
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Synonyms: |
Fog2-, FOG-2- |
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Gene:
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Zfpm2
Location:
Chr15:40655042-41104592 bp, + strand
Genetic Position: Chr15,
15.74 cM, cytoband C
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Abnormal lung development in the Zfpm2tm1Sho/Zfpm2tm1Sho mouse
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62879
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of sequences encoding all of the zinc finger motifs with a floxed neomycin-cytidine deaminase cassette. The floxed cassette was removed by crossing mutant animals to a cre deleter strain. Homozygous mutant embryos were detected by Southern blot analysis up to day E15.5. RNase protection assay showed an absence of Zfpm2 mRNA in hearts of E12.5 homozygous mutant embryos. (J:62879)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:62879
Tevosian SG et al.,
"FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium."
Cell 2000 Jun 23;101(7):729-39
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All: |
11 reference(s)
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Analysis Tools
