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| Nomenclature |
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Symbol:
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Igfalstm1Yrb
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Name:
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insulin-like growth factor binding protein, acid labile subunit;
targeted mutation 1, Yves R Boisclair
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MGI ID: |
MGI:2386180 |
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Synonyms: |
ALSKO |
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Gene:
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Igfals
Location:
Chr17:24878770-24882008 bp, + strand
Genetic Position: Chr17,
12.53 cM, cytoband A2-A3
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Igf1tm1Dlr/Igf1tm1Dlr Igfalstm1Yrb/Igfalstm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62710
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The sequences encoding the first 435 amino acids (including 16 out of 19 leucine repeats) corresponding to exon 1, intron 1, and part of exon 2 were replaced by a neomycin resistance cassette. Northern blot analysis showed an absence of gene transcripts in liver and kidneys of homozygous mutant animals. Plasma proteins from homozygous animals were unable to form cross-linking complexes which is consistent with deletion of the 16 leucine repeats. (J:62710)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:62710
Ueki I et al.,
"Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system."
Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6868-73
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All: |
7 reference(s)
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Analysis Tools
