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| Nomenclature |
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Symbol:
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Mmp12tm1Sds
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Name:
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matrix metallopeptidase 12;
targeted mutation 1, Steven D Shapiro
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MGI ID: |
MGI:2386174 |
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Synonyms: |
MME-, Mmp12-, MMP-12- |
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Gene:
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Mmp12
Location:
Chr9:7344381-7369499 bp, + strand
Genetic Position: Chr9,
2.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:32902
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of the majority of exon 2 with a PGK-neo cassette via homologous recombination. Gene transcription and protein production was absent in homozygous mutant animals as demonstrated by Northern and Western blot analysis of peritoneal macrophages and peritoneal fluid. (J:32902)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:32902
Shipley JM et al.,
"Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice."
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):3942-6
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All: |
41 reference(s)
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Analysis Tools
