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| Nomenclature |
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Symbol:
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Ttpatm1Hsz
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Name:
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tocopherol (alpha) transfer protein;
targeted mutation 1, Hiroshi Suzuki
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MGI ID: |
MGI:2386172 |
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Synonyms: |
alpha-TTP-, alpha-Ttptm1Csk, Ttpa- |
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Gene:
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Ttpa
Location:
Chr4:20007938-20030785 bp, + strand
Genetic Position: Chr4,
7.76 cM, cytoband A3
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Histological findings indicating neurodegeneration in Ttpatm1Hsz/Ttpatm1Hsz mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67046
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1, containing the translational start codon, was replaced with a neomycin selection cassette. Transcript was undetected by Northern blot analysis of liver samples obtained from homozygous mutant mice. (J:67046)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ttpa Mutation:
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7 strains or lines available |
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Notes |
ES cell lines = AB2.2 and A3-1. Mice from line L236 were derived from AB2.2 ES cells (129S7/SvEvBrd-Hprtb-m2). Mice from line C229 were derived from A3-1 ES cells (129X1/SvJ).
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| References |
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Original: |
J:67046
Jishage K et al.,
"Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice."
J Biol Chem 2001 Jan 19;276(3):1669-72
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All: |
11 reference(s)
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Analysis Tools
