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| Nomenclature |
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Symbol:
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Hsd11b2tm1Yko
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Name:
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hydroxysteroid 11-beta dehydrogenase 2;
targeted mutation 1, Yuri V Kotelevtsev
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MGI ID: |
MGI:2386169 |
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Synonyms: |
11Beta-HSD2- |
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Gene:
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Hsd11b2
Location:
Chr8:105518746-105523984 bp, + strand
Genetic Position: Chr8,
53.04 cM
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Hyperplasia and hypertrophy of the distal renal tubular epithelium in Hsd11b2tm1Yko/Hsd11b2tm1Yko mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53391
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 through 5 were replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of total kidney RNA. (J:53391)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hsd11b2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:53391
Kotelevtsev Y et al.,
"Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2."
J Clin Invest 1999 Mar;103(5):683-9
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All: |
10 reference(s)
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Analysis Tools
