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| Nomenclature |
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Symbol:
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Cd37tm1Hor
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Name:
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CD37 antigen;
targeted mutation 1, Ivan Horak
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MGI ID: |
MGI:2386160 |
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Synonyms: |
CD37- |
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Gene:
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Cd37
Location:
Chr7:45233632-45239115 bp, - strand
Genetic Position: Chr7,
29.2 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63315
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 3 and all of exon 4 were replaced with a PGK-neo cassette in the reverse orientation via homologous recombination. The gene targeting event results in deletion of part of the second transmembrane domain and the entire third transmembrane domain. Absence of gene expression in homozygous mutant animals was verified by Northern blot analysis of spleen mRNA using a Cd37 cDNA probe. (J:63315)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cd37 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:63315
Knobeloch KP et al.,
"Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions."
Mol Cell Biol 2000 Aug;20(15):5363-9
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All: |
7 reference(s)
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Analysis Tools
