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| Nomenclature |
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Symbol:
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Plcg2tm1Jni
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Name:
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phospholipase C, gamma 2;
targeted mutation 1, James N Ihle
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MGI ID: |
MGI:2386100 |
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Synonyms: |
PLCgamma2- |
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Gene:
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Plcg2
Location:
Chr8:117498291-117635140 bp, + strand
Genetic Position: Chr8,
64.26 cM
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Plcg2tm1Jni/Plcg2tm1Jni mice are protected from mBSA-induced arthritis
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63679
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3.8 kb region of the gene containing exon 2 was replaced with a neomycin resistance gene via homologous recombination. Spleen extracts from homozygous mutant animals did not contain protein product as determined by immunoprecipitation and Western blot analysis using antibodies directed against the C-terminus of the protein. (J:63679)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:63679
Wang D et al.,
"Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors."
Immunity 2000 Jul;13(1):25-35
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All: |
34 reference(s)
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Analysis Tools
