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| Nomenclature |
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Symbol:
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Eportm1.4Jtp
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Name:
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erythropoietin receptor;
targeted mutation 1.4, Josef T Prchal
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MGI ID: |
MGI:2386099 |
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Synonyms: |
EporTr, mthEPOR |
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Gene:
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Epor
Location:
Chr9:21958899-21963576 bp, - strand
Genetic Position: Chr9,
7.93 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67205
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele is a derivative of Eportm1.3Jtp in which cre-mediated recombination in vivo removed the PGK-neo cassette in the germline. The resulting allele, Eportm1.4Jtp, contains human sequence carrying a C5964G transversion mutation in exon 8. RT-PCR analysis of bone marrow detected truncated human transcript in homozygous mutant mice. (J:67205)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Epor Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:67205
Divoky V et al.,
"Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene."
Proc Natl Acad Sci U S A 2001 Jan 30;98(3):986-91
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All: |
2 reference(s)
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Analysis Tools
