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| Nomenclature |
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Symbol:
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Nfe2l1tm1Ywk
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Name:
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nuclear factor, erythroid derived 2,-like 1;
targeted mutation 1, Yuet Wai Kan
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MGI ID: |
MGI:2385929 |
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Synonyms: |
Nrf-1 - |
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Gene:
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Nfe2l1
Location:
Chr11:96817431-96829955 bp, - strand
Genetic Position: Chr11,
60.12 cM, cytoband D-E
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Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos with increased apoptosis
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46990
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into the terminal exon which encodes the DNA binding and leucine zipper domains. Northern blot and RT-PCR analysis demonstrated that a mutant 7 kb transcript was expressed from this allele, but immunoblot analysis confirmed that no detectable protein was encoded by this allele. (J:46990)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfe2l1 Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:46990
Chan JY et al.,
"Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice."
EMBO J 1998 Mar 16;17(6):1779-87
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All: |
4 reference(s)
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Analysis Tools
