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| Nomenclature |
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Symbol:
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Rxratm1Krc
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Name:
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retinoid X receptor alpha;
targeted mutation 1, Kenneth R Chien
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MGI ID: |
MGI:2385918 |
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Synonyms: |
RXRalphafl, RXRalphaflox, RXRalphafloxed |
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Gene:
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Rxra
Location:
Chr2:27676440-27762957 bp, + strand
Genetic Position: Chr2,
19.38 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48085
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was introduced into intron 3 and a floxed PGK-neo-tk cassette was introduced into intron 4 via homologous recombination. The PGK-neo-tk cassette was subsequently removed in correctly targeted cells by the transient expression of cre recombinase, leaving behind loxP sites flanking exon 4. (J:48085)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:48085
Chen J et al.,
"Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis."
Development 1998 May;125(10):1943-9
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All: |
20 reference(s)
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Analysis Tools
