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| Nomenclature |
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Symbol:
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Tg(Cyp19)C2-3Rrte
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Name:
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transgene insertion C2-3, Rajeshwar Rao Tekmal
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MGI ID: |
MGI:2385806 |
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Synonyms: |
int-5-aromatase, MMTV-int-5-aromatase transgene |
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Transgene:
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Tg(Cyp19)C2-3Rrte
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x BALB/c)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene was produced using a vector that contained the 2.4kb full-length mouse Cyp 19 cDNA in addition to a coding region that included -45 to -1 of 5' and a complete (860bp) 3' untranslated region under the control of a mouse mammary tumor virus promoter (MMTV). Multiple lines were generated, ranging in copy number from 1 to 30, estimated by Southern blot. This allele is representative of the high copy number variants and carries an estimated 20 copies of the gene in mammary gland tissue. (J:34063)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:34063
Tekmal RR et al.,
"Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities."
Cancer Res 1996 Jul 15;56(14):3180-5
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All: |
11 reference(s)
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Analysis Tools
