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| Nomenclature |
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Symbol:
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Ren1tm1Mgfs
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Name:
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renin 1 structural;
targeted mutation 1, Matthew G F Sharp
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MGI ID: |
MGI:2385802 |
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Synonyms: |
Ren-1d- |
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Gene:
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Ren1
Location:
Chr1:133350510-133360325 bp, + strand
Genetic Position: Chr1,
57.91 cM
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Altered renal morphology in Ren1tm1Mgfs/Ren1tm1Mgfs mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:41714
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced 92 bp of exon 3, the third intron, and 35 bp of exon 4. RT-PCR analysis of kidney did not detect mRNA. (J:41714)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ren1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:41714
Clark AF et al.,
"Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology."
J Biol Chem 1997 Jul 18;272(29):18185-90
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All: |
1 reference(s)
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Analysis Tools
