|
|
| Nomenclature |
|
Symbol:
|
Hsd11b1tm1Yko
|
|
Name:
|
hydroxysteroid 11-beta dehydrogenase 1;
targeted mutation 1, Yuri V Kotelevtsev
|
|
MGI ID: |
MGI:2385796 |
|
Synonyms: |
11beta-HSD-1-, 11beta-HSD1-, HSD1- |
|
Gene:
|
Hsd11b1
Location:
Chr1:193221630-193264054 bp, - strand
Genetic Position: Chr1,
97.67 cM
|
|
Hsd11b1tm1Yko/Hsd11b1tm1Ykomice show lipid accumulation in the liver
Show the 1 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:37960
|
|
Parent Cell Line:
| CGR8 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin resistance cassette containing a human beta actin promoter replaced a genomic sequence encompassing exons 3 and 4. Northern blot analyses of liver and brain did not detect mRNA in homozygous mutant mice. Enzyme function analyses of tissues from homozygous mutant mice detected less than 5% of wild-type enzyme levels in liver and did not detect enzyme in brain. (J:45085)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Hsd11b1 Mutation:
|
6 strains or lines available |
|
| References |
|
Original: |
J:37960
Kotelevtsev YV et al.,
"Inactivation of 11 beta-hydroxysteroid dehydrogenase type 1 by gene targeting in mice."
Endocr Res 1996;22(4):791-792
|
|
All: |
24 reference(s)
|
|
Analysis Tools
