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| Nomenclature |
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Symbol:
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Myd88tm1Aki
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Name:
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myeloid differentiation primary response gene 88;
targeted mutation 1, Shizuo Akira
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MGI ID: |
MGI:2385681 |
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Synonyms: |
MyD88-, MyD88 KO |
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Gene:
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Myd88
Location:
Chr9:119335934-119341411 bp, - strand
Genetic Position: Chr9,
71.33 cM
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Myd88tm1Aki/Myd88tm1Aki mice exhibit an increase in the number of bacteria in direct contact with the small intestinal epithelial surface
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48832
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a 1.0 kb genomic fragment that contained sequences encoding the C-terminal cytoplasmic domain of the protein. Northern blot analysis confirmed that the encoded mRNA could not be detected in the liver and spleen of homozygous mice. (J:48832, J:91950)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:48832
Adachi O et al.,
"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function."
Immunity 1998 Jul;9(1):143-50
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All: |
950 reference(s)
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Analysis Tools
