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| Nomenclature |
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Symbol:
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Tg(Rbp3-SV40)IT-2Jjw
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Name:
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transgene insertion IT-2, Jolene J Windle
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MGI ID: |
MGI:2385652 |
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Synonyms: |
IRBP-Tag |
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Transgene:
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Tg(Rbp3-SV40)IT-2Jjw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(BALB/cAnNHsd x C57BL/6NHsd)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: 2.7 kb of the SV40 T antigen gene fused to 1.9 kb of mouse RBP3 promoter sequences was used as the transgene. Promoter sequences from -1783 to +101 were used to drive expression of the transgene in photoreceptor cells. Northern blot analysis confirmed transgene expression in the retina and pineal of transgenic animals. (J:60231)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Transgenic animals develop retinal and pineal tumors by 10-12 weeks of age with 100% penetrance. Transgenic animals carrying the greatest transgene copy number (15-50) also displayed a 25%-30% decrease in body weight compared to non-transgenic animals.
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| References |
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Original: |
J:60231
Howes KA et al.,
"Photoreceptor cell tumors in transgenic mice."
Invest Ophthalmol Vis Sci 1994 Feb;35(2):342-51
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All: |
1 reference(s)
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Analysis Tools
