Tg(APPSWE)2576Kha
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(APPSWE)2576Kha
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Name:
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transgene insertion 2576, Karen Hsiao Ashe
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MGI ID: |
MGI:2385631 |
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Synonyms: |
APP695swe, APPK670N,M671L, APPSw, APPswe Tg2576, hAPP, K670N/M671L, Tg2576, Tg(APPSWE)2576HKahs, Tg(APPSWE)2576Kahs, Tg(HuAPP695.K670-M671L)2576, TgN(APPSWE)2576 |
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Transgene:
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Tg(APPSWE)2576Kha
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. (J:29880, J:80638)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:80638
Hsiao K et al.,
"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice."
Science 1996 Oct 4;274(5284):99-102
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All: |
406 reference(s)
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Analysis Tools
