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| Nomenclature |
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Symbol:
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Tg(Tuba1-MAPT)14Vle
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Name:
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transgene insertion 14, Virginia M Y Lee
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MGI ID: |
MGI:2385585 |
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Synonyms: |
Talpha1-3RT |
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Transgene:
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Tg(Tuba1-MAPT)14Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A murine Tuba1 promoter was adjoined to a minigene comprised of the complete coding region of the MAPT gene that included modified intronic sequence flanking exons 2 and 3 to drive expression of the downstream gene construct in the CNS. Western blot analysis showed the MAPT protein to be expressed at levels approximately 5.5 fold higher than the endogenous mouse counterpart. (J:78400)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:78400
Higuchi M et al.,
"Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration."
Neuron 2002 Aug 1;35(3):433-46
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All: |
2 reference(s)
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Analysis Tools
