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| Nomenclature |
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Symbol:
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Tg(Prnp-MAPT)43Vle
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Name:
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transgene insertion 43, Virginia M Y Lee
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MGI ID: |
MGI:2385566 |
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Transgene:
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Tg(Prnp-MAPT)43Vle
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing a cDNA sequence to human MAPT (fetal tau, Tau44 isoform) under the control of the mouse Prnp promtoer was used to create transgenic animals. Quantitative Western blot analysis showed hyperphosphorylated, insoluble MAPT protein to be widely expressed in neurons of the CNS at levels approximately 10 fold higher than the endogenous mouse counterpart. (J:61052)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Three founder lines were generated - lines 7, 27 and 43. Hemizygous mice from line 27 are not viable beyond 3 months and were not characterized in J:61052. Hemizygous mice from line 7 are phenotypically similar to line 43, however inclusions in the spinal cord are smaller and less abundant than in line 43.
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| References |
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Original: |
J:61052
Ishihara T et al.,
"Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform."
Neuron 1999 Nov;24(3):751-62
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All: |
4 reference(s)
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Analysis Tools
