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| Nomenclature |
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Symbol:
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Prss8tm1.1Hum
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Name:
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protease, serine, 8 (prostasin);
targeted mutation 1.1, Edith Hummler
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MGI ID: |
MGI:2384520 |
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Synonyms: |
Prss8delta |
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Gene:
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Prss8
Location:
Chr7:127925725-127930113 bp, - strand
Genetic Position: Chr7,
69.84 cM
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Early postnatal lethality and skin abnormalities in Prss8tm1.1Hum/Prss8tm1.2Hum Tg(KRT14-cre)1Ipc/0 mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75109
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Parent Cell Line:
| GS1 (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Breeding of mice carrying Prss8tm1Ipt with transgenic mice expressing cre via the EIIa promoter resulted in the excision of the floxed region containing exons 3 through 5. The FRT flanked neo cassette inserted into intron 2 remained intact. (J:75109)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prss8 Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:75109
Rubera I et al.,
"A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus."
Genesis 2002 Feb;32(2):173-6
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All: |
4 reference(s)
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Analysis Tools
