|
|
| Nomenclature |
|
Symbol:
|
Pitx2tm1Rsd
|
|
Name:
|
paired-like homeodomain transcription factor 2;
targeted mutation 1, Michael G Rosenfeld
|
|
MGI ID: |
MGI:2384494 |
|
Synonyms: |
Pitx2-, Pitx2LacZ |
|
Gene:
|
Pitx2
Location:
Chr3:129199878-129219591 bp, + strand
Genetic Position: Chr3,
57.84 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:57673
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The gene was disrupted by replacement of the entire homeodomain and C-terminus with an in-frame lacZ-neo cassette via homologous recombination. Southern blot analysis identified homozygous mutant embryos up to E15. X-gal staining of mutant embryos demonstrated the expression pattern of the lacZ targeted insert is similar to that of endogenous protein. (J:57673)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Pitx2 Mutation:
|
12 strains or lines available |
|
| References |
|
Original: |
J:57673
Lin CR et al.,
"Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis."
Nature 1999 Sep 16;401(6750):279-82
|
|
All: |
8 reference(s)
|
|
Analysis Tools
