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| Nomenclature |
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Symbol:
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Egr1tm1Jmi
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Name:
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early growth response 1;
targeted mutation 1, Jeffrey Milbrandt
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MGI ID: |
MGI:2384433 |
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Synonyms: |
egr-1-, Egr1-, Egr-10, Egr-1ko, NGFI-A- |
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Gene:
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Egr1
Location:
Chr18:34859823-34864984 bp, + strand
Genetic Position: Chr18,
18.76 cM, cytoband C/D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:24948
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into a coding exon upstream of the DNA-binding domain via homologous recombination. The targeted mutation introduces several stop codons resulting protein truncation upstream of the DNA-binding domain. Gene expression and protein product were not observed in homozygous mutant ES cells. (J:24948)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line = AB1 (129S7/SvEvBrd-Hprt+) or D3 (129S2/SvPas).
Phenotypic Similarity to Human Syndrome: Myeloproliferative disorder J:123870 background involves: 129 * C57BL/6
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| References |
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Original: |
J:24948
Lee SL et al.,
"Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A."
J Biol Chem 1995 Apr 28;270(17):9971-7
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All: |
60 reference(s)
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Analysis Tools
