|
|
| Nomenclature |
|
Symbol:
|
Ppargtm1.1Gonz
|
|
Name:
|
peroxisome proliferator activated receptor gamma;
targeted mutation 1.1, Frank J Gonzales
|
|
MGI ID: |
MGI:2384321 |
|
Synonyms: |
PPARgammafl |
|
Gene:
|
Pparg
Location:
Chr6:115361221-115490401 bp, + strand
Genetic Position: Chr6,
53.41 cM, cytoband E3-F1
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:75777
|
|
Parent Cell Line:
| RW-4 (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: Animals heterozygous for Ppargtm1Gonz were crossed to an EIIa-cre transgenic line to delete the floxed PGK-neo cassette. The deletion event leaves behind single loxP sites flanking exon 2. Southern blot analysis confirmed the removal of PGK-neo in offspring. (J:75777)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Pparg Mutation:
|
11 strains or lines available |
|
| References |
|
Original: |
J:75777
Akiyama TE et al.,
"Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux."
Mol Cell Biol 2002 Apr;22(8):2607-19
|
|
All: |
46 reference(s)
|
|
Analysis Tools
