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| Nomenclature |
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Symbol:
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Cfhtm1Mbo
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Name:
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complement component factor h;
targeted mutation 1, Marina Botto
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MGI ID: |
MGI:2384179 |
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Synonyms: |
Cfh-, fH- |
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Gene:
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Cfh
Location:
Chr1:140085855-140183411 bp, - strand
Genetic Position: Chr1,
61.62 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78193
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a neomycin selection cassette. The absence of encoded protein in homozygous mutant mice was confirmed by Western blot analysis. (J:78193)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cfh Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:78193
Pickering MC et al.,
"Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H."
Nat Genet 2002 Aug;31(4):424-8
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All: |
23 reference(s)
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Analysis Tools
