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| Nomenclature |
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Symbol:
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Cdkn2atm2.1Rdp
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Name:
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cyclin-dependent kinase inhibitor 2A;
targeted mutation 2.1, Ronald DePinho
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MGI ID: |
MGI:2384177 |
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Synonyms: |
Ink4a-, p16-, p16Ink4a-, p16Ink4a- |
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Gene:
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Cdkn2a
Location:
Chr4:89274473-89294653 bp, - strand
Genetic Position: Chr4,
42.15 cM, cytoband C3-C6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71394
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 alpha, specific to the p16Ink4a alternative splice product, was replaced by a floxed neo cassette. Cre mediated recombination removed the floxed neo cassette. The absence of the p16Ink4a and the presence of p19ARF was confirmed by Western blot analysis of extracts from homozygous mutant mouse embryonic fibroblasts. (J:71394)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:71394
Sharpless NE et al.,
"Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis."
Nature 2001 Sep 6;413(6851):86-91
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All: |
41 reference(s)
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Analysis Tools
