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| Nomenclature |
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Symbol:
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Cdkn2atm1.1Brn
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Name:
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cyclin-dependent kinase inhibitor 2A;
targeted mutation 1.1, Anton Berns
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MGI ID: |
MGI:2384165 |
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Synonyms: |
Ink4a-, Ink4a*, p16-, p16Ink4a--, p16Ink4a*, p16Ink4a KO |
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Gene:
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Cdkn2a
Location:
Chr4:89274473-89294653 bp, - strand
Genetic Position: Chr4,
42.15 cM, cytoband C3-C6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71393
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele was generated by excising the floxed neo cassette from Cdkn2atm1Brn by breeding with transgenic mice expressing cre. The presence of a stop codon at position 101 of the p16Ink4a open reading frame precluded the translation of the fourth ankyrin motif of p16Ink4a. While p16Ink4a was undetected by Western blot analysis or immunoprecipitation, the expression of p19ARF was unaffected in homozygous mutant mice. (J:71393)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:71393
Krimpenfort P et al.,
"Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice."
Nature 2001 Sep 6;413(6851):83-6
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All: |
11 reference(s)
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Analysis Tools
