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| Nomenclature |
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Symbol:
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Cdkn2atm2Brn
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Name:
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cyclin-dependent kinase inhibitor 2A;
targeted mutation 2, Anton Berns
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MGI ID: |
MGI:2384163 |
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Synonyms: |
ArfF, Ink4a/ArfF, Ink4aflox, p16INK4a-ARFfl |
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Gene:
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Cdkn2a
Location:
Chr4:89274473-89294653 bp, - strand
Genetic Position: Chr4,
42.15 cM, cytoband C3-C6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:71393
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were inserted 1.0 kb upstream of exon 2 and 1.5 kb downstream of exon 3. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Cdkn2atm2.1Brn. (J:71393)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:71393
Krimpenfort P et al.,
"Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice."
Nature 2001 Sep 6;413(6851):83-6
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All: |
12 reference(s)
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Analysis Tools
