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| Nomenclature |
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Symbol:
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Tg(ML5sHEL)5Ccg
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Name:
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transgene insertion 5, Christopher C Goodnow
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MGI ID: |
MGI:2384160 |
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Synonyms: |
MD5, ML5, ML-5, sHEL, solHEL |
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Transgene:
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Tg(ML5sHEL)5Ccg
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a mouse metallothionein I promoter. The mouse metallothionein I promoter is active during embryonic, fetal, and adult life, and can be induced to higher levels of transcription by heavy metals. Mice carrying the transgene had measurable, soluble chicken lysozyme in their serum. The line chosen for study (ML-5) had the highest serum lysozyme concentrations. (J:78308)
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Inheritance: | |
Not Specified |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78308
Goodnow CC et al.,
"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice."
Nature 1988 Aug 25;334(6184):676-82
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All: |
53 reference(s)
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Analysis Tools
