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| Nomenclature |
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Symbol:
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Mpztm1Msch
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Name:
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myelin protein zero;
targeted mutation 1, Melitta Schachner
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MGI ID: |
MGI:2384133 |
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Synonyms: |
P0- |
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Gene:
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Mpz
Location:
Chr1:171150711-171161130 bp, + strand
Genetic Position: Chr1,
79.05 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:3234
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 encoding the signal peptide was replaced with a neomycin resistance gene via homologous recombination. Southern blot analysis revealed several copies of the targeting vector had integrated as a concatemer in a head-to-tail manner. Western blot analysis of peripheral nerve proteins from homozygous mutant animals confirmed the absence of gene expression. The null allele was further verified by immunohistochemical analysis of femoral nerve sections from homozygous mutant animals using a polyclonal antibody to the protein. No immunoreactive staining was observed. (J:3234)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mpz Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:3234
Giese KP et al.,
"Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons."
Cell 1992 Nov 13;71(4):565-76
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All: |
37 reference(s)
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Analysis Tools
