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| Nomenclature |
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Symbol:
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Pafah1b1tm2Awb
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Name:
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platelet-activating factor acetylhydrolase, isoform 1b, subunit 1;
targeted mutation 2, Anthony Wynshaw-Boris
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MGI ID: |
MGI:2384060 |
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Synonyms: |
Lis1-loxP, Pafah1b1-loxP, Pafah1b1loxPex3-6 |
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Gene:
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Pafah1b1
Location:
Chr11:74673949-74724670 bp, - strand
Genetic Position: Chr11,
45.76 cM, cytoband B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49531
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed PGK-neo cassette was inserted into intron 2 and a third loxP site was introduced into intron 6 via homologous recombination. This allele is hypomorphic, because of disruption of transcription or splicing by the insertion of a phosphoglycerate kinase neomycin cassette from the targeting vector into the second intron (J:82268). (J:49531)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:49531
Hirotsune S et al.,
"Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality [see comments]"
Nat Genet 1998 Aug;19(4):333-9
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All: |
9 reference(s)
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Analysis Tools
