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| Nomenclature |
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Symbol:
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Fggtm1Fjc
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Name:
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fibrinogen gamma chain;
targeted mutation 1, Francis J Castellino
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MGI ID: |
MGI:2384029 |
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Synonyms: |
FG-, Fib- |
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Gene:
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Fgg
Location:
Chr3:83007896-83015049 bp, + strand
Genetic Position: Chr3,
36.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64396
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette. Western blot analysis of blood plasma showed the absence of the gamma polypeptide, preventing the formation of the fibrinogen heterodimer in homozygous mutant mice. (J:64396)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fgg Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:64396
Ploplis VA et al.,
"A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice."
Am J Pathol 2000 Sep;157(3):703-8
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All: |
11 reference(s)
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Analysis Tools
