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| Nomenclature |
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Symbol:
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Ercc2tm1Jhjh
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Name:
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excision repair cross-complementing rodent repair deficiency, complementation group 2;
targeted mutation 1, Jan H J Hoeijmakers
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MGI ID: |
MGI:2183947 |
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Synonyms: |
TTD-, XPD0 |
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Gene:
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Ercc2
Location:
Chr7:19382010-19395694 bp, + strand
Genetic Position: Chr7,
9.62 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45017
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: All of exons 17 through 21 and a portion of exon 22 were replaced by a cassette containing neo and hprt transgenes. The insertion is upstream of sequence encoding the DNA helicase domains 4 through 6 and the putative DNA-binding domain. The potential excision of the cassette generates a frameshift mutation via the splicing of exons 16 and 23. The targeting vector was designed such that it would not interfere with the Klc3 locus on the antisense strand. (J:45017)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ercc2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:45017
de Boer J et al.,
"Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality."
Cancer Res 1998 Jan 1;58(1):89-94
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All: |
5 reference(s)
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Analysis Tools
