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| Nomenclature |
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Symbol:
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Ercc1tm1Jhjh
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Name:
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excision repair cross-complementing rodent repair deficiency, complementation group 1;
targeted mutation 1, Jan H J Hoeijmakers
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MGI ID: |
MGI:2183944 |
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Synonyms: |
Ercc1- |
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Gene:
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Ercc1
Location:
Chr7:19344778-19356524 bp, + strand
Genetic Position: Chr7,
9.6 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:41161
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette. Expression analysis showed an absence of transcript in mouse embryonic fibroblasts derived from homozygous mutant mice. Further analysis showed that transcription of the antisense gene was unaffected by the targeting event. (J:41161)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ercc1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:41161
Weeda G et al.,
"Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence."
Curr Biol 1997 Jun 1;7(6):427-39
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All: |
11 reference(s)
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Analysis Tools
