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| Nomenclature |
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Symbol:
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Xpatm1Tnka
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Name:
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xeroderma pigmentosum, complementation group A;
targeted mutation 1, Kiyoji Tanaka
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MGI ID: |
MGI:2183931 |
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Synonyms: |
XPA- |
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Gene:
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Xpa
Location:
Chr4:46155347-46196311 bp, - strand
Genetic Position: Chr4,
24.49 cM, cytoband C2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28709
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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(CBA x C57BL/6)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 4 was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of splenocyte extracts. (J:28709)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Xpa Mutation:
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7 strains or lines available |
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Notes |
ES cell line = F1/1 ES (established from the F1 hybrid of CBA and C57BL/6).
Phenotypic Similarity to Human Syndrome: Cutaneous Malignant Melanoma in mice homozygous for this allele and hemizygous for Tg(KRT14-Kitl)1Takk
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| References |
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Original: |
J:28709
Nakane H et al.,
"High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene."
Nature 1995 Sep 14;377(6545):165-8
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All: |
30 reference(s)
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Analysis Tools
