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| Nomenclature |
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Symbol:
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Tg(PMP22)C22Clh
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Name:
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transgene insertion C22, Clare Huxley
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MGI ID: |
MGI:2183770 |
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Synonyms: |
C22 |
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Transgene:
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Tg(PMP22)C22Clh
Location:
unknown
Genetic Position: Chr8,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/Ca)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Founder C22 carries 8 copies of the human transgene on chromosome 8 with an expression pattern similar to that of the endogenous mouse gene. The expression level of each human transgene is approximately 0.4X that of one mouse gene. (J:78221)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78221
Huxley C et al.,
"Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA."
Hum Mol Genet 1996 May;5(5):563-9
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All: |
9 reference(s)
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Analysis Tools
