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| Nomenclature |
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Symbol:
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Tg(UcpDta)1Kz
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Name:
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transgene insertion 1, Leslie P Kozak
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MGI ID: |
MGI:2183746 |
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Synonyms: |
BATless, UCP-DTA |
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Transgene:
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Tg(UcpDta)1Kz
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Incorporation of a toxic transgene, diphtheria toxin-A-chain (Dta), coupled to regulatory elements of the gene for brown adipose tissue specific uncoupling protein (Ucp) resulted in the ablation of brown adipose tissue (BAT). Specifically, Dta was inserted into the first exon of Ucp1 at position +120 to create the vector. (J:78211)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78211
Lowell BB et al.,
"Development of obesity in transgenic mice after genetic ablation of brown adipose tissue."
Nature 1993 Dec 23-30;366(6457):740-2
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All: |
17 reference(s)
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Analysis Tools
