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| Nomenclature |
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Symbol:
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Tg(Sod1*G86R)M1Jwg
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Name:
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transgene insertion M1, Jon W Gordon
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MGI ID: |
MGI:2183736 |
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Synonyms: |
M1, Tg(Sod1*G85R)M1Jwg, Tg(Sod1-G86R)M1Jwg |
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Transgene:
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Tg(Sod1*G86R)M1Jwg
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The entire mouse Sod1 gene with an engineered point mutation in exon 4 resulting in a glycine to arginine substitution at residue 86 (G86R) was used as the transgene. Mutation G86R corresponds to the SOD1 G86R mutation found in some cases of human amyotrophic lateral sclerosis (ALS) patients. RT-PCR analysis detected expression of the transgene in brain, spinal cord, and other tissues.
The missense mutation is a point mutation in exon 4 resulting in a glycine-86 to arginine substitution, which corresponds to amino acid position 86 in the human SOD1 protein. Transgenics exhibit widespread high expression of the transgene and do not exhibit diminished SOD1 activity. .
(J:22628)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:22628
Ripps ME et al.,
"Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis."
Proc Natl Acad Sci U S A 1995 Jan 31;92(3):689-93
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All: |
19 reference(s)
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Analysis Tools
